[IUR cooperation] Particle Cloud silk free 3D printing technology helps biomedical users to carry out research on bionic artificial bone scaffold

2022-03-10 11:30

A team composed of the department of orthopaedics of Xijing Hospital of the Air Force Military Medical University(Xi'an),the imaging department of Luoyang Central Hospital,affiliated to Zhengzhou University,the department of orthopaedics of Linyi People's Hospital,Shandong province,the department of orthopaedics of the General Hospital of the Northern Theater of the Chinese People's Liberation Army(Shenyang),and the all army Orthopaedic Research Institute of the Air Force Military Medical University(Xi'an)used the biological 3D printer of Xi'an Particle Cloud Biotechnology Co.,Ltd.to prepare hydrogel scaffolds containing cells,The effect of 3D bioprinting on osteogenic differentiation of hydrogel scaffolds containing BMSCs was discussed,and the paper"the effect of 3D bioprinting on osteogenic differentiation of gelatin/sodium alginate/lithium magnesium silicate composite cell hydrogel scaffolds"was published in the Chinese Journal of Trauma.






Bone has the ability to repair itself,but it is difficult to recover a large area of bone defects unless bone grafting is used.The"gold standard"of bone defect repair is autologous bone transplantation,but the problems of secondary operation and limited bone source limit its wide application.Compared with the traditional bone substitute materials,the Particle Cloud biological 3D printer adopts the silk free printing technology,supports the freely proportioned composite printing slurry,accurately controls the three-dimensional molding of a variety of biological materials and living cells,and can accurately control the porosity and three-dimensional structure of the scaffold according to the designed printing program and model.




Particle Cloud biological 3D printer


The experimental results show that the hydrogel has pore structure and high water content,which can keep the internal cells alive.It is an ideal three-dimensional cell culture carrier.3D bioprinting structure can promote the proliferation and osteogenic differentiation of BMSCs in scaffolds.Biological scaffolds have good compatibility in vivo and can be degraded slowly.3D bioprinting can promote the development of implanted BMSCs hydrogel scaffolds to osteogenesis.This is a good hint for the research and development of tissue engineering scaffold materials.However,due to the high water content of hydrogel materials,the strength of the scaffolds is far from meeting the requirements of direct implantation and repair of large bone defects.Next,a balance needs to be made between improving the strength of biomaterials and maintaining the activity of carrying cells.The strength of scaffolds should be further improved by modifying the materials or changing the printing structure.
Particle Cloud is committed to the research and development of 3D printing renewable artificial bone core technology,and has accumulated rich application experience,and is good at 3D printing technology of biomaterials.The independently constructed 3D printing bioceramic scaffold has been verified by a series of in vitro and in vivo experiments.The scaffold has a series of advantages,such as bionic pore structure,good mechanical strength,good biocompatibility,biodegradability,and promotion of new bone formation.




Particle Cloud 3D printed bioceramic scaffold


In the future,Particle Cloud will continue to cooperate sincerely with college users,give full play to its own technology and equipment advantages,help colleges and universities to carry out cutting-edge research on 3D printing technology,support college users to continuously explore in the field of biological additive manufacturing,and publish more influential papers.

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